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Expression of Fgf and Tgfβ signaling related genes during embryonic endochondral ossification

pmid: 15963767
Expression of Fgf and Tgfβ signaling related genes during embryonic endochondral ossification
Disturbed fibroblast growth factor (Fgf) and transforming growth factor beta (Tgfbeta) signaling lead to a variety of human skeletal disorders. To reveal the possible function and interaction of these signaling systems we have started to analyze the expression patterns of signaling factors, antagonists, receptors and transducers of these pathways in forelimbs of mouse embryos and compared them to the expression of established markers including Ihh. In addition to defining their expression domains in the developing bone, our study identified new subpopulations of chondrocytes characterized by the expression of distinct combinations of markers.
- Max Planck Society Germany
- Max Planck Institute of Neurobiology Germany
- University of Duisburg-Essen Germany
Osteoblasts, Gene Expression Regulation, Developmental, Bone Morphogenetic Protein Receptors, Embryo, Mammalian, Receptors, Fibroblast Growth Factor, Fibroblast Growth Factors, Mice, Chondrocytes, Osteogenesis, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Forelimb, Animals, Inhibins, Biologie, Receptors, Transforming Growth Factor beta, Signal Transduction
Osteoblasts, Gene Expression Regulation, Developmental, Bone Morphogenetic Protein Receptors, Embryo, Mammalian, Receptors, Fibroblast Growth Factor, Fibroblast Growth Factors, Mice, Chondrocytes, Osteogenesis, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Forelimb, Animals, Inhibins, Biologie, Receptors, Transforming Growth Factor beta, Signal Transduction
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