The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice
Copyright policy )The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice
Abstract The expression of a defective LPS response gene Lps and the major urinary protein (Mup-1) are concordantly inherited in backcross (C3H/HeJ × C57BL/6J)F1 × C3H/HeJ mice, indicating genetic linkage of these loci. Mup-1 is known to be linked to the brown coat color locus on chromosome 4 in mice; thus Lps can now be assigned to chromosome 4. A value of 0.06 ± 0.02 has been estimated for the recombination frequency between Mup-1 and Lps. We have used the polysyndactyly (Ps) mutation further to localize Lps on chromosome 4. Lps is located between the Mup-1 and Ps loci.
- Jackson Laboratory United States
- University of California, Irvine United States
Serology: Antigen, Lipopolysaccharides, Linkage:, Genes: b - Brown, Genes, MHC Class II, C57BL/6, Genes-Immune-Response, 610, Mice, Inbred Strains, Strains: C3H/HE, Lymphocyte Activation, Ps - Polysyndactyly, Mice, 616, lps - Lipopolysaccharide responses, Escherichia coli, Animals, Escherichia-Coli: im, Mice-Inbred-C3H, Polysaccharides-Bacterial, Mup-a-1 Mup, Mice, Inbred C3H, Unknown:, English-Abstract, Polysaccharides, Bacterial, Syndactylia: fg, Chromosome Mapping, Lymphocyte-Transformation, Proteinuria, Proteinuria: fg, Chromosome-Mapping, Mup*Al, Mice-Inbred-Strains, Syndactyly, Hereditary Factors:
Serology: Antigen, Lipopolysaccharides, Linkage:, Genes: b - Brown, Genes, MHC Class II, C57BL/6, Genes-Immune-Response, 610, Mice, Inbred Strains, Strains: C3H/HE, Lymphocyte Activation, Ps - Polysyndactyly, Mice, 616, lps - Lipopolysaccharide responses, Escherichia coli, Animals, Escherichia-Coli: im, Mice-Inbred-C3H, Polysaccharides-Bacterial, Mup-a-1 Mup, Mice, Inbred C3H, Unknown:, English-Abstract, Polysaccharides, Bacterial, Syndactylia: fg, Chromosome Mapping, Lymphocyte-Transformation, Proteinuria, Proteinuria: fg, Chromosome-Mapping, Mup*Al, Mice-Inbred-Strains, Syndactyly, Hereditary Factors:
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