Bioactive oxygen-bridged cyclooctadienes from endophytic fungus Phomopsis sp. BCC 45011

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2015 English Publisher:Elsevier BVJournal:Tetrahedron, volume 71, pages 9,112-9,116 (issn: 0040-4020,

Authors: Jittra Kornsakulkarn; Wiwat Somyong; Sumalee Supothina; Nattawut Boonyuen; Chawanee Thongpanchang;

doi: 10.1016/j.tet.2015.10.015

Bioactive oxygen-bridged cyclooctadienes from endophytic fungus Phomopsis sp. BCC 45011

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Abstract

Abstract Three new oxygen-bridged cyclooctadiene containing compounds, 5–7, phomoxydienes A–C, and two new dothiorelones I (8) and J (9), together with 10 known compounds were isolated from endophytic fungus, Phomopsis sp. BCC 45011. Structures were determined by NMR spectroscopic and MS spectrometric analyses. Mycoepoxydiene (1), deacetylmycoepoxydiene (2), phomoxydienes A (5) and C (7), and cytosporone E (12) displayed antimalarial and cytotoxic activities while 1893 A (3) and cytosporone P (13) showed only cytotoxic and antimalarial activity, respectively.

Related Organizations

National Science and Technology Development Agency
Thailand
National Center for Genetic Engineering and Biotechnology
Thailand

15 Research products, page 1 of 2

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