Expression analysis of the entire MMP and TIMP gene families during mouse tissue development
Copyright policy )Expression analysis of the entire MMP and TIMP gene families during mouse tissue development
Matrix metalloproteinases (MMPs) and adamalysins (ADAMs) cleave many extracellular proteins, including matrix, growth factors, and receptors. We profiled the RNA levels of every MMP, several ADAMs, and inhibitors of metalloproteinases (TIMPs and RECK) in numerous mouse tissues during development and in the uterus during pregnancy. Observations include: most secreted MMPs are expressed at low to undetectable levels in tissues, whereas membrane‐bound MMPs, ADAMs and inhibitors are abundant; almost every proteinase and inhibitor is present in the uterus or placenta at some time during gestation; the mouse collagenases mColA and mColB are found exclusively in the uterus and testis; and each tissue has its unique signature of proteinase and inhibitor expression.
- University of East Anglia United Kingdom
- Western University Canada
- University of Calgary Canada
Male, Adamalysin, Placenta, Gene Expression, Mice, Inbred Strains, Tissue inhibitor of metalloproteinase, GPI-Linked Proteins, Real-time polymerase chain reaction, Mice, Pregnancy, Animals, Tissue Distribution, RNA, Messenger, Membrane Glycoproteins, Gene Expression Profiling, Uterus, Tissue Inhibitor of Metalloproteinases, Matrix Metalloproteinases, Matrix metalloproteinase, Mice, Inbred C57BL, Animals, Newborn, Mouse tissue development, Female
Male, Adamalysin, Placenta, Gene Expression, Mice, Inbred Strains, Tissue inhibitor of metalloproteinase, GPI-Linked Proteins, Real-time polymerase chain reaction, Mice, Pregnancy, Animals, Tissue Distribution, RNA, Messenger, Membrane Glycoproteins, Gene Expression Profiling, Uterus, Tissue Inhibitor of Metalloproteinases, Matrix Metalloproteinases, Matrix metalloproteinase, Mice, Inbred C57BL, Animals, Newborn, Mouse tissue development, Female
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