Drosophila melanogaster diphenol oxidase A2: gene structure and homology with the mouse mast-cell tum− transplantation antigen, P91A
Copyright policy )Drosophila melanogaster diphenol oxidase A2: gene structure and homology with the mouse mast-cell tum− transplantation antigen, P91A
The Drosophila melanogaster diphenol oxidase (DOX) A2-encoding gene (Dox-A2) is involved in catecholamine metabolism, melanin formation and sclerotization of the cuticle. Insect phenol oxidases (POX) are well studied biochemically, but not genetically and molecularly. The Dox-A2 (2-53.9) gene is the first insect POX-encoding gene to be cloned and sequenced. It encodes a protein product unique among currently known POX. The deduced protein, however, exhibits extensive similarity (58-81%) to the mouse mast cell tum- antigen, P91A [Lurquin et al., Cell 58 (1989) 293-303] and may identify the normal mouse protein as a DOX.
- University of Virginia United States
Mice, Drosophila melanogaster, Base Sequence, Histocompatibility Antigens, Molecular Sequence Data, Animals, Amino Acid Sequence, Mast Cells, Poly A, Sequence Alignment, TATA Box, Catechol Oxidase
Mice, Drosophila melanogaster, Base Sequence, Histocompatibility Antigens, Molecular Sequence Data, Animals, Amino Acid Sequence, Mast Cells, Poly A, Sequence Alignment, TATA Box, Catechol Oxidase
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