BEGAIN (Brain-enriched Guanylate Kinase-associated Protein), a Novel Neuronal PSD-95/SAP90-binding Protein
Copyright policy )BEGAIN (Brain-enriched Guanylate Kinase-associated Protein), a Novel Neuronal PSD-95/SAP90-binding Protein
PSD-95/SAP90 is a synaptic membrane-associated guanylate kinase with three PDZ, one SH3, and one guanylate kinase (GK) domain. PSD-95/SAP90 binds various proteins through the PDZ domains and organizes synaptic junctions. PSD-95/SAP90 also interacts with the postsynaptic density (PSD) fraction-enriched protein, named SAPAP (also called GKAP and DAP), through the GK domain. SAPAP is Triton X-100-insoluble and recruits PSD-95/SAP90 into the Triton X-100-insoluble fraction in the transfected cells, suggesting that SAPAP may fix PSD-95/SAP90 to the PSD. Here we report a novel protein interacting with the GK domain of PSD-95/SAP90, BEGAIN. BEGAIN is specifically expressed in brain and enriched in the PSD fraction. BEGAIN is Triton X-100-soluble in the transfected cells but is recruited to the Triton X-100-insoluble fraction by SAPAP when coexpressed with PSD-95/SAP90. BEGAIN may be a novel PSD component associated with the core complex of PSD-95/SAP90 and SAPAP.
- Osaka University Japan
Neurons, Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Nerve Tissue Proteins, Saccharomyces cerevisiae, Rats, SAP90-PSD95 Associated Proteins, COS Cells, Animals, Amino Acid Sequence, Carrier Proteins, Disks Large Homolog 4 Protein, Subcellular Fractions
Neurons, Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Nerve Tissue Proteins, Saccharomyces cerevisiae, Rats, SAP90-PSD95 Associated Proteins, COS Cells, Animals, Amino Acid Sequence, Carrier Proteins, Disks Large Homolog 4 Protein, Subcellular Fractions
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