<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Tau deficiency leads to the upregulation of BAF‐57, a protein involved in neuron‐specific gene repression

descriptionPublicationkeyboard_double_arrow_right Article 23 Mar 2010 Spain English Publisher:WileyJournal:FEBS Letters, volume 584, pages 2,265-2,270 (issn: 0014-5793, eissn: 1873-3468,

Authors: Gómez de Barreda, Elena; Dawson, Hana N.; Vitek, Michael P.; Ávila, Jesús;

doi: 10.1016/j.febslet.2010.03.032

pmid: 20338169

handle: 10261/252832

Tau deficiency leads to the upregulation of BAF‐57, a protein involved in neuron‐specific gene repression

- Summary
- Subjects
- Related research
  (10)
- Metrics

tips_and_updates
Recommended

Abstract

Although tau is mainly located in the cell cytoplasm, mostly bound to tubulin, it may also be found in the nucleus of neurons. Hence, we tested whether tau might play a role in regulating the expression of certain genes by comparing gene expression in mice containing or lacking the tau protein. Our results identified a significant difference in the expression of the smarce1 gene, which codes for the BAF‐57 protein, a protein involved in the repression of neuron specific genes. These data suggest a role for tau in neuron maturation.

Country

Spain

Related Organizations

View all View all

Keywords

Cell Nucleus, Mice, Knockout, Neurons, Cytoplasm, Axonogenesis, Chromosomal Proteins, Non-Histone, Tau k.o., Gene Expression, tau Proteins, Up-Regulation, Cytoskeletal Proteins, Mice, Neuron maturation, Tubulin, Nuclear tau, Animals, BAF-57, Gene expression

10 Research products, page 1 of 1

Microtubule-associated protein
2017IsRelatedTo
Microtubule-associated protein
2017IsRelatedTo
Microtubule-associated protein
2017IsRelatedTo
Microtubule-associated protein
2017IsRelatedTo
Microtubule-associated protein tau
2017IsRelatedTo
Microtubule-associated protein tau
2017IsRelatedTo
Microtubule-associated protein tau
2017IsRelatedTo
Microtubule-associated protein
2017IsRelatedTo
Microtubule-associated protein tau
2017IsRelatedTo
Microtubule-associated protein
2017IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	27
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%

Usage byUsageCounts

visibility	views	25
download	downloads	8

25
views
8
downloads
Powered by