Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-κB activation and invasive prostate carcinoma
Copyright policy )Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-κB activation and invasive prostate carcinoma
Prostate cancer is one of the most common neoplasias in men. The tumor suppressor Par-4 is an important negative regulator of the canonical NF-κB pathway and is highly expressed in prostate. Here we show that Par-4 expression is lost in a high percentage of human prostate carcinomas, and this occurs in association with phosphatase and tensin homolog deleted from chromosome 10 (PTEN) loss. Par-4 null mice, similar to PTEN-heterozygous mice, only develop benign prostate lesions, but, importantly, concomitant Par-4 ablation and PTEN-heterozygosity lead to invasive prostate carcinoma in mice. This strong tumorigenic cooperation is anticipated in the preneoplastic prostate epithelium by an additive increase in Akt activation and a synergistic stimulation of NF-κB. These results establish the cooperation between Par-4 and PTEN as relevant for the development of prostate cancer and implicate the NF-κB pathway as a critical event in prostate tumorigenesis.
Male, NF-kappa B, PTEN Phosphohydrolase, Prostatic Neoplasms, Adenocarcinoma, Mice, Mutation, Animals, Humans, Neoplasm Invasiveness, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt, Protein Kinase C
Male, NF-kappa B, PTEN Phosphohydrolase, Prostatic Neoplasms, Adenocarcinoma, Mice, Mutation, Animals, Humans, Neoplasm Invasiveness, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt, Protein Kinase C
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