Molecular interactions of all possible regioisomers of synthetic myo-inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1997 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 7, pages 2,709-2,714 (issn: 0960-894X,

Authors: Choi, G; CHANG, YOUNG TAE; Chung, SK; Choi, KY;

doi: 10.1016/s0960-894x(97)10060-9

Molecular interactions of all possible regioisomers of synthetic myo-inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase

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Abstract

Abstract Inositol 1,4,5-trisphosphate 3-kinase (IP3K) catalyzes the ATP-dependent phosphorylation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P 3 ] generating inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P 4 ]. The inhibitory effects of all possible 38 regioisomers of inositol phosphates [InsPn] on the IP3K activity have been examined. The correlations between inhibitory potencies and their structural features allowed the assessment of the environment in the active site of IP3K, thus resulting in a proposed binding site model.

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Pohang University of Science and Technology
Korea (Republic of)

Keywords

ANALOGS, RECEPTOR, TETRAKISPHOSPHATES, TRISPHOSPHATE, POTENT, MYOINOSITOL 1,4,5-TRISPHOSPHATE

14 Research products, page 1 of 2

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