SARS-CoV-2 Mproinhibition by a zinc ion: structural features and hints for drug design
Copyright policy )SARS-CoV-2 Mproinhibition by a zinc ion: structural features and hints for drug design
The first structure of the SARS-CoV-2 main protease in complex with an isolated zinc ion provides solid ground for the design of potent and selective metal-conjugated inhibitors.
- University of Florence Italy
- New York University Italy
- National Institute for Nuclear Physics Italy
Protein Conformation, instruct, Crystallography, X-Ray, Catalysis, Research and Innovation action, Binding Sites; COVID-19; Coronavirus 3C Proteases; Crystallography, X-Ray; Humans; Protein Conformation; SARS-CoV-2; Zinc, Materials Chemistry, Humans, European Commission, Instruct-ERIC, Knowmad Institut, Coronavirus 3C Proteases, EC, Binding Sites, SARS-CoV-2, H2020, Metals and Alloys, COVID-19, projects, General Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Zinc, Ceramics and Composites, iNEXT-Discovery
Protein Conformation, instruct, Crystallography, X-Ray, Catalysis, Research and Innovation action, Binding Sites; COVID-19; Coronavirus 3C Proteases; Crystallography, X-Ray; Humans; Protein Conformation; SARS-CoV-2; Zinc, Materials Chemistry, Humans, European Commission, Instruct-ERIC, Knowmad Institut, Coronavirus 3C Proteases, EC, Binding Sites, SARS-CoV-2, H2020, Metals and Alloys, COVID-19, projects, General Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Zinc, Ceramics and Composites, iNEXT-Discovery
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!