Induction and molecular signature of pathogenic TH17 cells
Copyright policy )Induction and molecular signature of pathogenic TH17 cells
Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T(H)17 cells are main drivers of autoimmune tissue injury. However, not all T(H)17 cells are pathogenic; in fact, T(H)17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of TGF-β3 by developing T(H)17 cells was dependent on IL-23, which together with IL-6 induced very pathogenic T(H)17 cells. Moreover, TGF-β3-induced T(H)17 cells were functionally and molecularly distinct from TGF-β1-induced T(H)17 cells and had a molecular signature that defined pathogenic effector T(H)17 cells in autoimmune disease.
- Stanford University United States
- Harvard Medical School United States
- Harvard University United States
- Translational Health Science and Technology Institute India
- Howard Hughes Medical Institute United States
Inflammation, Interleukin-6, Interleukin-17, 610, Cell Differentiation, Interleukin-23, Article, Autoimmune Diseases, Transforming Growth Factor beta1, Mice, Transforming Growth Factor beta3, Animals, Humans, Th17 Cells
Inflammation, Interleukin-6, Interleukin-17, 610, Cell Differentiation, Interleukin-23, Article, Autoimmune Diseases, Transforming Growth Factor beta1, Mice, Transforming Growth Factor beta3, Animals, Humans, Th17 Cells
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