Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Copyright policy )Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
- University of Oxford United Kingdom
- Wellcome Trust United Kingdom
- Guy's and St Thomas' NHS Foundation Trust United Kingdom
- NHS Lothian United Kingdom
- University of Queensland Australia
/dk/atira/pure/subjectarea/asjc/1300/1311, Carrier proteins, Nod2 Signaling Adaptor Protein, 610, Autophagy-Related Proteins, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Cohort Studies, Crohn Disease, GTP-Binding Proteins, Risk Factors, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, Homeodomain Proteins, Extracellular Matrix Proteins, Biological markers, HLA-A Antigens, Interleukin-12 Subunit p40, Intracellular Signaling Peptides and Proteins, 1103 Clinical Sciences, Receptors, Interleukin, Homeodomain proteins, Ulcerative colitis, Extracellular matrix proteins, Case-Control Studies, Colitis, Ulcerative, Carrier Proteins, Biomarkers
/dk/atira/pure/subjectarea/asjc/1300/1311, Carrier proteins, Nod2 Signaling Adaptor Protein, 610, Autophagy-Related Proteins, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Cohort Studies, Crohn Disease, GTP-Binding Proteins, Risk Factors, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, Homeodomain Proteins, Extracellular Matrix Proteins, Biological markers, HLA-A Antigens, Interleukin-12 Subunit p40, Intracellular Signaling Peptides and Proteins, 1103 Clinical Sciences, Receptors, Interleukin, Homeodomain proteins, Ulcerative colitis, Extracellular matrix proteins, Case-Control Studies, Colitis, Ulcerative, Carrier Proteins, Biomarkers
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