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Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma
Copyright policy ) Y, Chang; E, Cesarman; M S, Pessin; F, Lee; J, Culpepper; D M, Knowles; P S, Moore;
Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.
- Columbia University United States
- New York City Department of Health and Mental Hygiene United States
- King’s University United States
Male, Acquired Immunodeficiency Syndrome, Base Composition, Herpesvirus 4, Human, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Nucleic Acid Hybridization, Polymerase Chain Reaction, Herpesvirus 2, Saimiriine, Blotting, Southern, Open Reading Frames, DNA, Viral, Humans, Female, Amino Acid Sequence, Cloning, Molecular, Sarcoma, Kaposi, Herpesviridae, Retrospective Studies
Male, Acquired Immunodeficiency Syndrome, Base Composition, Herpesvirus 4, Human, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Nucleic Acid Hybridization, Polymerase Chain Reaction, Herpesvirus 2, Saimiriine, Blotting, Southern, Open Reading Frames, DNA, Viral, Humans, Female, Amino Acid Sequence, Cloning, Molecular, Sarcoma, Kaposi, Herpesviridae, Retrospective Studies
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.01% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.01% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.01% views 188 downloads 119 - 188views119downloads
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
Impulse provided by BIP!viewsViews provided by UsageCounts
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