The DUG gene of Drosophila melanogaster encodes a structural and functional homolog of the S. cerevisiae SUG1 predicted ATPase associated with the 26S proteasome
Copyright policy )The DUG gene of Drosophila melanogaster encodes a structural and functional homolog of the S. cerevisiae SUG1 predicted ATPase associated with the 26S proteasome
The DUG gene of Drosophila encodes a putative ATPase that is a structural and functional homolog of the yeast SUG1 product. When introduced into S. cerevisiae, the Drosophila DUG gene rescued the lethality associated with a SUG1 mutant. Anti-DUG antibodies recognized a protein that migrated in high molecular weight complexes, along with components of the 26S proteasome, and also immunoprecipitated components of the 26S proteasome from embryonic extracts. Proteins recognized by the affinity-purified antibody raised against DUG were localized in either a punctate cytoplasmic distribution or in the nucleus, depending on the cell type, consistent with the subcellular localization of the 26S proteasome in various cell types.
- Stanford University United States
Adenosine Triphosphatases, Proteasome Endopeptidase Complex, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Macromolecular Substances, Molecular Sequence Data, Gene Expression Regulation, Developmental, Genes, Insect, Saccharomyces cerevisiae, Cross Reactions, Precipitin Tests, Fungal Proteins, Repressor Proteins, Drosophila melanogaster, Animals, Cloning, Molecular, Conserved Sequence, Gene Deletion, Peptide Hydrolases, Subcellular Fractions
Adenosine Triphosphatases, Proteasome Endopeptidase Complex, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Macromolecular Substances, Molecular Sequence Data, Gene Expression Regulation, Developmental, Genes, Insect, Saccharomyces cerevisiae, Cross Reactions, Precipitin Tests, Fungal Proteins, Repressor Proteins, Drosophila melanogaster, Animals, Cloning, Molecular, Conserved Sequence, Gene Deletion, Peptide Hydrolases, Subcellular Fractions
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