Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
Copyright policy )Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
Life and death and quality control When cells are subjected to too much stress, they curl up their toes and die. Lu et al. describe a clever strategy cells use to stay alive as long as they are not stressed for too long. The cells' quality-control machinery will activate a so-called death receptor when defective proteins accumulate within the cell, a sign of stress—but they will wait until the proteins have built up for a good long time. If stress is relieved soon enough, levels of the death receptor decay back to normal, and the cells stay alive; otherwise, R.I.P. Science , this issue p. 98
- University of California, San Francisco United States
- GENENTECH INC United States
- Howard Hughes Medical Institute United States
- University of Adelaide Australia
570, General Science & Technology, 1.1 Normal biological development and functioning, RNA Stability, Messenger, 610, Apoptosis, Protein Serine-Threonine Kinases, Inbred C57BL, Ligands, TNF-Related Apoptosis-Inducing Ligand, Mice, Receptors, Endoribonucleases, Genetics, Animals, Humans, RNA, Messenger, Cancer, Biological Sciences, Endoplasmic Reticulum Stress, HCT116 Cells, Mice, Inbred C57BL, Receptors, TNF-Related Apoptosis-Inducing Ligand, Caspases, Unfolded Protein Response, RNA, Biochemistry and Cell Biology, Generic health relevance, Transcription Factor CHOP
570, General Science & Technology, 1.1 Normal biological development and functioning, RNA Stability, Messenger, 610, Apoptosis, Protein Serine-Threonine Kinases, Inbred C57BL, Ligands, TNF-Related Apoptosis-Inducing Ligand, Mice, Receptors, Endoribonucleases, Genetics, Animals, Humans, RNA, Messenger, Cancer, Biological Sciences, Endoplasmic Reticulum Stress, HCT116 Cells, Mice, Inbred C57BL, Receptors, TNF-Related Apoptosis-Inducing Ligand, Caspases, Unfolded Protein Response, RNA, Biochemistry and Cell Biology, Generic health relevance, Transcription Factor CHOP
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