Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex
Copyright policy )Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex
The glial cell line-derived neurotrophic factor (GDNF) ligands (GDNF, Neurturin [NTN], and Persephin [PSP]) signal through a multicomponent receptor system composed of a high-affinity binding component (GFRalpha1-GFRalpha4) and a common signaling component (RET). Here, we report the identification of Artemin, a novel member of the GDNF family, and demonstrate that it is the ligand for the former orphan receptor GFRalpha3-RET. Artemin is a survival factor for sensory and sympathetic neurons in culture, and its expression pattern suggests that it also influences these neurons in vivo. Artemin can also activate the GFRalpha1-RET complex and supports the survival of dopaminergic midbrain neurons in culture, indicating that like GDNF (GFRalpha1-RET) and NTN (GFRalpha2-RET), Artemin has a preferred receptor (GFRalpha3-RET) but that alternative receptor interactions also occur.
- WASHINGTON UNIVERSITY
- Washington University in St. Louis United States
- University of Mary United States
Neurons, Binding Sites, Glial Cell Line-Derived Neurotrophic Factor Receptors, Cell Survival, Neuroscience(all), Molecular Sequence Data, Nerve Tissue Proteins, Embryo, Mammalian, Ligands, Mice, Animals, Newborn, Models, Chemical, Mesencephalon, Animals, Drosophila Proteins, Humans, Amino Acid Sequence, Glial Cell Line-Derived Neurotrophic Factor, Nerve Growth Factors, Cloning, Molecular, Cells, Cultured
Neurons, Binding Sites, Glial Cell Line-Derived Neurotrophic Factor Receptors, Cell Survival, Neuroscience(all), Molecular Sequence Data, Nerve Tissue Proteins, Embryo, Mammalian, Ligands, Mice, Animals, Newborn, Models, Chemical, Mesencephalon, Animals, Drosophila Proteins, Humans, Amino Acid Sequence, Glial Cell Line-Derived Neurotrophic Factor, Nerve Growth Factors, Cloning, Molecular, Cells, Cultured
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