New loci associated with chronic hepatitis B virus infection in Han Chinese
Copyright policy )New loci associated with chronic hepatitis B virus infection in Han Chinese
Chronic hepatitis B virus (HBV) infection is a challenging global health problem. To identify genetic loci involved in chronic HBV infection, we designed a three-phase genome-wide association study in Han Chinese populations. The discovery phase included 951 HBV carriers (cases) and 937 individuals who had naturally cleared HBV infection (controls) and was followed by independent replications with a total of 2,248 cases and 3,051 controls and additional replications with 1,982 HBV carriers and 2,622 controls from the general population. We identified two new loci associated with chronic HBV infection: rs3130542 at 6p21.33 (near HLA-C, odds ratio (OR) = 1.33, P = 9.49 × 10(-14)) and rs4821116 at 22q11.21 (in UBE2L3, OR = 0.82, P = 1.71 × 10(-12)). Additionally, we replicated the previously identified associations of HLA-DP and HLA-DQ variants at 6p21.32 with chronic HBV infection. These findings highlight the importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.
- Nanjing Medical University China (People's Republic of)
- Shanghai Jiao Tong University China (People's Republic of)
- State Key Laboratory of Respiratory Disease China (People's Republic of)
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Biomedical Research Council Singapore
Male, HLA-DP Antigens, HLA-C Antigens, Polymorphism, Single Nucleotide, Hepatitis B, Chronic, Asian People, Genetic Loci, Case-Control Studies, HLA-DQ Antigens, Carrier State, Ubiquitin-Conjugating Enzymes, Humans, Chromosomes, Human, Pair 6, Female, Genetic Predisposition to Disease, Genome-Wide Association Study
Male, HLA-DP Antigens, HLA-C Antigens, Polymorphism, Single Nucleotide, Hepatitis B, Chronic, Asian People, Genetic Loci, Case-Control Studies, HLA-DQ Antigens, Carrier State, Ubiquitin-Conjugating Enzymes, Humans, Chromosomes, Human, Pair 6, Female, Genetic Predisposition to Disease, Genome-Wide Association Study
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