Bulges in left-handed G-quadruplexes
Copyright policy )Bulges in left-handed G-quadruplexes
Abstract G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
- French National Centre for Scientific Research France
- Nanyang Technological University Singapore
- INSTITUT POLYTECHNIQUE DE PARIS France
- École Polytechnique France
- Biochemistry Laboratory France
Models, Molecular, MESH: DNA / chemistry*, Crystallography, X-Ray, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, MESH: Nuclear Magnetic Resonance, Structural Biology, MESH: Models, Nucleotide Motifs, Nuclear Magnetic Resonance, Biomolecular, Crystallography, Molecular Biology/Structural Biology [q-bio.BM], MESH: Crystallography, MESH: G-Quadruplexes*, Molecular, :Biological sciences [Science], DNA, 540, 620, G-Quadruplexes, MESH: Nucleotide Motifs, X-Ray, MESH: Sugars / chemistry, Sugars, Biomolecular
Models, Molecular, MESH: DNA / chemistry*, Crystallography, X-Ray, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, MESH: Nuclear Magnetic Resonance, Structural Biology, MESH: Models, Nucleotide Motifs, Nuclear Magnetic Resonance, Biomolecular, Crystallography, Molecular Biology/Structural Biology [q-bio.BM], MESH: Crystallography, MESH: G-Quadruplexes*, Molecular, :Biological sciences [Science], DNA, 540, 620, G-Quadruplexes, MESH: Nucleotide Motifs, X-Ray, MESH: Sugars / chemistry, Sugars, Biomolecular
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