Probable exclusion of the cortexin-encoding gene as a candidate for mouse neurological mutants: nervous, tottering and motor neuron degeneration
Copyright policy )Probable exclusion of the cortexin-encoding gene as a candidate for mouse neurological mutants: nervous, tottering and motor neuron degeneration
We have tested the gene encoding cortexin, Ctxn, which maps to chromosome 8, as a candidate for the mouse neurological mutants: nervous (nr), tottering (tg) plus tottering-leaner (tgla), and motor neuron degeneration (mnd) by Northern blot analysis of brain poly(A)+ RNA and direct polymerase chain reaction (PCR) sequencing. No difference from wild-type was seen in any of these mutants. Based upon these observations, we conclude that Ctxn is not involved in the genetic defects found in nr, tg or mnd mice.
- University of California, Los Angeles United States
- The University of Texas Southwestern Medical Center United States
Brain Chemistry, Mice, Inbred BALB C, Base Sequence, Homozygote, Molecular Sequence Data, Blotting, Northern, Mice, Mice, Neurologic Mutants, Mutation, Nerve Degeneration, Animals, Intercellular Signaling Peptides and Proteins, Point Mutation, Motor Neuron Disease, Peptides
Brain Chemistry, Mice, Inbred BALB C, Base Sequence, Homozygote, Molecular Sequence Data, Blotting, Northern, Mice, Mice, Neurologic Mutants, Mutation, Nerve Degeneration, Animals, Intercellular Signaling Peptides and Proteins, Point Mutation, Motor Neuron Disease, Peptides
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