Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow
Copyright policy )Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow
Polycystic diseases and left-right (LR) axis malformations are frequently linked to cilia defects. Renal cysts also arise in mice and frogs lacking Bicaudal C (BicC), a conserved RNA-binding protein containing K-homology (KH)domains and a sterile alpha motif (SAM). However, a role for BicC in cilia function has not been demonstrated. Here, we report that targeted inactivation of BicC randomizes left-right (LR) asymmetry by disrupting the planar alignment of motile cilia required for cilia-driven fluid flow. Furthermore,depending on its SAM domain, BicC can uncouple Dvl2 signaling from the canonical Wnt pathway, which has been implicated in antagonizing planar cell polarity (PCP). The SAM domain concentrates BicC in cytoplasmic structures harboring RNA-processing bodies (P-bodies) and Dvl2. These results suggest a model whereby BicC links the orientation of cilia with PCP, possibly by regulating RNA silencing in P-bodies.
- University of Hohenheim Germany
- École Polytechnique Fédérale de Lausanne EPFL Switzerland
Mice, Knockout, Nodal Protein, Dishevelled Proteins, Cell Polarity, RNA-Binding Proteins, Xenopus Proteins, Embryo, Mammalian, Phosphoproteins, Cell Line, Mice, Inbred C57BL, Wnt Proteins, Mice, Animals, Humans, RNA Interference, Cilia, Carrier Proteins, Adaptor Proteins, Signal Transducing, Body Patterning, Signal Transduction
Mice, Knockout, Nodal Protein, Dishevelled Proteins, Cell Polarity, RNA-Binding Proteins, Xenopus Proteins, Embryo, Mammalian, Phosphoproteins, Cell Line, Mice, Inbred C57BL, Wnt Proteins, Mice, Animals, Humans, RNA Interference, Cilia, Carrier Proteins, Adaptor Proteins, Signal Transducing, Body Patterning, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).109 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!