Uncommon GNAQ, MMP8, AKT3, EGFR, and PIK3R1 Mutations in Thyroid Cancers
Copyright policy )Uncommon GNAQ, MMP8, AKT3, EGFR, and PIK3R1 Mutations in Thyroid Cancers
Frequent mutations in the GNAQ, MMP8, Akt3, EGFR, and PIK3R1 genes have been reported in human cancers but mostly have not been well examined in thyroid cancer. Selected exons of GNAQ, MMP8, AKT3, EGFR, and PIK3R1 genes were sequenced in various thyroid cancers. We found a G2203A EGFR mutation, resulting in a G735S amino acid change, in one of 21 (5%) papillary thyroid cancer samples. We did not find any mutation in the MMP8 gene, but observed a frequent SNP A259G (K87E) genotype switch in various types of thyroid cancer samples. We did not find any mutation in the GNAQ, AKT3, and PIK3R1 genes in various types of thyroid cancer. No mutation in these genes was found in 12 cell lines derived from various types of thyroid cancer. Therefore, unlike in other cancers, mutations in these genes are uncommon in thyroid cancer.
- DePaul University United States
- Johns Hopkins Medicine United States
- Johns Hopkins University United States
- Indiana University School of Medicine United States
- The University of Texas Medical Branch at Galveston United States
Class I Phosphatidylinositol 3-Kinases, GTP-Binding Protein alpha Subunits, Neoplasm Proteins, ErbB Receptors, Phosphatidylinositol 3-Kinases, Matrix Metalloproteinase 8, Mutation, Biomarkers, Tumor, GTP-Binding Protein alpha Subunits, Gq-G11, Thyroid Neoplasms, Proto-Oncogene Proteins c-akt
Class I Phosphatidylinositol 3-Kinases, GTP-Binding Protein alpha Subunits, Neoplasm Proteins, ErbB Receptors, Phosphatidylinositol 3-Kinases, Matrix Metalloproteinase 8, Mutation, Biomarkers, Tumor, GTP-Binding Protein alpha Subunits, Gq-G11, Thyroid Neoplasms, Proto-Oncogene Proteins c-akt
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