ADAMTS‐7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF‐α and NF‐κB P65
Copyright policy )ADAMTS‐7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF‐α and NF‐κB P65
ADAMTS‐7 has been reported to exaggerate cartilage degeneration and to be associated with TNF‐α and NF‐κB signaling pathway. In this study we compared the expression of ADAMTS‐7, TNF‐α, and Phospho‐NF‐κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS‐7, TNF‐α, and Phospho‐NF‐κB was significantly upregulated in ONFH patients’ articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS‐7 level appears to be positively associated with expression of TNF‐α and Phospho‐NF‐κB P65 in cartilage, which may imply its association with cartilage destruction of ONFH.
- Shandong Women’s University China (People's Republic of)
- Qilu Hospital of Shandong University China (People's Republic of)
Aged, 80 and over, Male, ADAMTS7 Protein, Osteonecrosis, Transcription Factor RelA, Femur Head, Middle Aged, Gene Expression Regulation, Enzymologic, ADAM Proteins, Cartilage, Tumor Necrosis Factors, Pathology, RB1-214, Humans, Female, Research Article, Aged
Aged, 80 and over, Male, ADAMTS7 Protein, Osteonecrosis, Transcription Factor RelA, Femur Head, Middle Aged, Gene Expression Regulation, Enzymologic, ADAM Proteins, Cartilage, Tumor Necrosis Factors, Pathology, RB1-214, Humans, Female, Research Article, Aged
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