N-Methyl-d-aspartate Receptors Regulate a Group of Transiently Expressed Genes in the Developing Brain
Copyright policy )N-Methyl-d-aspartate Receptors Regulate a Group of Transiently Expressed Genes in the Developing Brain
Mammalian brain development requires the transmission of electrical signals between neurons via the N-methyl-d-aspartate (NMDA) class of glutamate receptors. However, little is known about how NMDA receptors carry out this role. Here we report the first genes shown to be regulated by physiological levels of NMDA receptor function in developing neurons in vivo: NMDA receptor-regulated gene 1 (NARG1), NARG2, and NARG3. These genes share several striking regulatory features. All three are expressed at high levels in the neonatal brain in regions of neuronal proliferation and migration, are dramatically down-regulated during early postnatal development, and are down-regulated by NMDA receptor function. NARG2 and NARG3 appear to be novel, while NARG1 is the mammalian homologue of a yeast N-terminal acetyltransferase that regulates entry into the G(o) phase of the cell cycle. The results suggest that highly specific NMDA receptor-dependent regulation of gene expression plays an important role in the transition from proliferation of neuronal precursors to differentiation of neurons.
- Wayne State University United States
- Wayne State College United States
Expressed Sequence Tags, Mice, Knockout, Neurons, DNA, Complementary, Cell Cycle, Brain, Down-Regulation, Gene Expression Regulation, Developmental, Nerve Tissue Proteins, Blotting, Northern, Mice, Acetyltransferases, Cell Movement, Animals, Drosophila, N-Terminal Acetyltransferase E, Cell Division, In Situ Hybridization, N-Terminal Acetyltransferase A, Gene Library
Expressed Sequence Tags, Mice, Knockout, Neurons, DNA, Complementary, Cell Cycle, Brain, Down-Regulation, Gene Expression Regulation, Developmental, Nerve Tissue Proteins, Blotting, Northern, Mice, Acetyltransferases, Cell Movement, Animals, Drosophila, N-Terminal Acetyltransferase E, Cell Division, In Situ Hybridization, N-Terminal Acetyltransferase A, Gene Library
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