VEGFD regulates blood vascular development by modulating SOX18 activity
Copyright policy )VEGFD regulates blood vascular development by modulating SOX18 activity
Key PointsHaploinsufficiency of Sox18 reveals an important role for VEGFD in regulating blood vascular development in vivo in vertebrates. VEGFD acts through mitogen-activated protein kinase kinase–extracellular signal-regulated kinase to modulate the activity and nuclear concentration of endothelial-specific transcription factor SOX18.
- University of Queensland Australia
- University of Melbourne Australia
- University of Queensland Australia
- Peter MacCallum Cancer Centre Australia
- University of Queensland Australia
Male, 1303 Biochemistry, 571, Embryo, Nonmammalian, 2720 Hematology, Vascular Endothelial Growth Factor D, Neovascularization, Physiologic, Sox18, 1307 Cell Biology, Animals, Genetically Modified, Mice, Vegfd, SOXF Transcription Factors, Animals, Gene Regulatory Networks, Zebrafish, 2403 Immunology, Arteriovenous differentiation, Gene Expression Regulation, Developmental, Zebrafish Proteins, Embryo, Mammalian, Mice, Inbred C57BL, Blood Vessels, Blood vessel, Female, MEK-ERK
Male, 1303 Biochemistry, 571, Embryo, Nonmammalian, 2720 Hematology, Vascular Endothelial Growth Factor D, Neovascularization, Physiologic, Sox18, 1307 Cell Biology, Animals, Genetically Modified, Mice, Vegfd, SOXF Transcription Factors, Animals, Gene Regulatory Networks, Zebrafish, 2403 Immunology, Arteriovenous differentiation, Gene Expression Regulation, Developmental, Zebrafish Proteins, Embryo, Mammalian, Mice, Inbred C57BL, Blood Vessels, Blood vessel, Female, MEK-ERK
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