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Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy

descriptionPublicationkeyboard_double_arrow_right Article 24 Sep 2009 English Publisher:Informa UK LimitedJournal:Growth Factors (issn: 0897-7194,

Authors: Luís Belo; Cristina Catarino; Irene Rebelo; Susana Rocha; Alexandre Quintanilha; Elisabeth Castro; Belmiro Patrício; +1 Authors

doi: 10.1080/08977190903184670 , 10.3109/08977190903184670

pmid: 19919522

Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy

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Abstract

Few studies evaluated angiogenic/anti-angiogenic factors and endothelial (dys)function in both maternal and umbilical cord blood (UCB) in preeclampsia (PE). We aimed to clarify the role of placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (VEGFR-1) and tissue plasminogen activator (tPA), by evaluating them in maternal and UCB in 42 normal and 46 preeclamptic (PEc) cases. In PE, maternal and UCB PlGF were significantly lower; maternal VEGF, sVEGFR-1 and tPA were significantly higher. In UCB, sVEGFR-1 and tPA were significantly higher in PEc cases, while VEGF and PlGF were significantly lower. A significant correlation between maternal and UCB sVEGFR-1, and between sVEGFR-1 and tPA both in maternal and UCB, was observed in PEc cases. In maternal and UCB circulation in PE, a close interaction seems to exist between endothelial dysfunction and angiogenesis disturbance, and sVEGFR-1 seems to play a central role in those disturbances.

Related Organizations

Universidade do Porto
Portugal
University of Porto
Portugal
Instituto de Biologia Molecular e Celular
Portugal

Keywords

Adult, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1, Infant, Newborn, Neovascularization, Physiologic, Gestational Age, Pregnancy Proteins, Fetal Blood, Young Adult, Fetus, Pre-Eclampsia, Pregnancy, Case-Control Studies, Tissue Plasminogen Activator, Infant, Small for Gestational Age, Humans, Female, Placenta Growth Factor

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	34
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%