Combined haploid and insertional mutation screen in the zebrafish
Copyright policy )Combined haploid and insertional mutation screen in the zebrafish
AbstractTo identify genes required for development of the brain and somites, we performed a pilot screen of gynogenetic haploid zebrafish embryos produced from mothers mutagenized by viral insertion. We describe an efficient method to identify new mutations and the affected gene. In addition, we report the results of a small‐scale screen that identified five genes required for brain development, including novel alleles of nagie oko, pou5f1, ribosomal protein L36, and n‐cadherin, as well as a novel allele of the laminin g1 gene that is required for normal skeletal muscle fiber organization and somite patterning. genesis 40:231–240, 2004. © 2004 Wiley‐Liss, Inc.
- Whitehead Institute for Biomedical Research United States
- Neurosciences Institute United States
- University of Oregon United States
- University of Göttingen Germany
- Massachusetts Institute of Technology United States
Male, Brain, Haploidy, Zebrafish Proteins, Models, Biological, Mutagenesis, Insertional, Phenotype, Somites, Guanylate Cyclase, Mutation, Animals, Female, Cloning, Molecular, Alleles, Zebrafish, Body Patterning
Male, Brain, Haploidy, Zebrafish Proteins, Models, Biological, Mutagenesis, Insertional, Phenotype, Somites, Guanylate Cyclase, Mutation, Animals, Female, Cloning, Molecular, Alleles, Zebrafish, Body Patterning
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