The 5-HTTPR*S/*L Polymorphism and Aggressive Behavior in Alzheimer Disease
Copyright policy )The 5-HTTPR*S/*L Polymorphism and Aggressive Behavior in Alzheimer Disease
Aggressive behavior in Alzheimer disease (AD) has been linked to dysfunction of serotonin neurotransmission. Homozygosity for the long variant (*L) of an identified biallelic polymorphism of the serotonin transporter promoter region (5-HTTPR) is associated with increased expression of the transporter protein and increased speed of response to serotonin reuptake inhibitor treatment.To determine whether the *L/*L genotype and the *L allele are associated with an increased risk of aggressive symptoms in patients with AD.Case-control study.University hospital geriatric psychiatry inpatient program and Alzheimer disease research center.Fifty-eight patients with AD with a history of aggressive behavior and 79 never-aggressive patients with AD with comparable severity of cognitive impairment.The 5-HTTPR genotype and allele frequency.The *L/*L genotype was significantly associated with aggression in patients with AD (odds ratio, 2.8; 95% confidence interval, 1.2-6.5). Similar results were obtained for *L allele frequency.The 5-HTTPR*L allele and *L/*L genotype may predispose patients with AD to develop aggressive behavior.
- University of Pittsburgh United States
Aged, 80 and over, Male, Serotonin Plasma Membrane Transport Proteins, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Membrane Transport Proteins, Nerve Tissue Proteins, Aggression, Gene Frequency, Alzheimer Disease, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Carrier Proteins, Promoter Regions, Genetic, Aged
Aged, 80 and over, Male, Serotonin Plasma Membrane Transport Proteins, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Membrane Transport Proteins, Nerve Tissue Proteins, Aggression, Gene Frequency, Alzheimer Disease, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Carrier Proteins, Promoter Regions, Genetic, Aged
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