Allele frequency of HLA‐B39 in the Japanese population and identification of a novel B39 allele, B*3923
Copyright policy )Allele frequency of HLA‐B39 in the Japanese population and identification of a novel B39 allele, B*3923
Abstract: A new HLA‐B39 allele, B*3923, was found in the Japanese population. Compared with B*39022, the new allele had a single point mutation at position 503 in exon 3 with an amino acid substitution, Gln144Arg. To determine B39 allele frequency in Japanese, 275 B39‐positive samples from 3277 Japanese individuals were examined by polymerase chain reaction using microtitre plate hydribization (PCR‐MPH) and single‐strand conformation polymorphism (PCR‐SSCP). The frequency of B*3923 was estimated to be 0.4% in B39 alleles of the Japanese population. B*3923 was found in samples from four Japanese individuals, all of whom have DRB1*1406 (Note).
- Hoshi University Japan
- Gulf Coast Regional Blood Center United States
Molecular Sequence Data, HLA-B39 Antigen, Asian People, Gene Frequency, Haplotypes, Japan, HLA-B Antigens, Humans, Point Mutation, Oligonucleotide Probes, Polymorphism, Single-Stranded Conformational
Molecular Sequence Data, HLA-B39 Antigen, Asian People, Gene Frequency, Haplotypes, Japan, HLA-B Antigens, Humans, Point Mutation, Oligonucleotide Probes, Polymorphism, Single-Stranded Conformational
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