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Science Translational Medicine
Article
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Science Translational Medicine
Article . 2009 . Peer-reviewed
Data sources: Crossref
Science Translational Medicine
Article . 2010
Data sources: Europe PubMed Central
Science Translational Medicine
Article
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A β-Arrestin–Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation

descriptionPublicationkeyboard_double_arrow_right Article 07 Oct 2009 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Translational Medicine, volume 1 (issn: 1946-6234, eissn: 1946-6242, Copyright policy )
Authors: Ling Yuan; Louis M. Luttrell; Louis M. Luttrell; Robert F. Spurney; Pat Flannery; Robert J. Lefkowitz; Robert J. Lefkowitz; +2 Authors

doi: 10.1126/scitranslmed.3000071

pmid: 20368153

pmc: PMC2852200

A β-Arrestin–Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation

Abstract

A biased agonist binds to the seven-transmembrane parathyroid hormone receptor to trigger certain downstream effects but not others, potentially avoiding undesirable side effects.

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Keywords

Male, Mice, Knockout, Bone Development, Arrestins, Mice, Bone Density, GTP-Binding Proteins, Animals, beta-Arrestins, Receptor, Parathyroid Hormone, Type 1, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 191
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
191
Top 10%
Top 10%
Top 1%
bronze