Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines
Copyright policy )Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines
The K562 cell line (chronic myeloid leukemia), sensitive to chemotherapy (non-MDR), and the Lucena cell line, resistant to chemotherapy (MDR) were investigated. The results suggest that both cell lines possess CD34+CD38- profiles of hematopoietic stem cell markers. The promoter regions of ABCB1, ABCG2 and ABCC1 genes contain binding sites for the Oct-4 transcripton factor, which is also considered a marker of tumor stem cells. Lucena cells showed an over-expression of the ABCB1 gene and a high expression of the Oct-4, ABCG2 and ABCC1 genes as compared to K562 cells.
ATP Binding Cassette Transporter, Subfamily B, Binding Sites, Membrane Glycoproteins, Gene Expression Regulation, Leukemic, Antigens, CD34, ADP-ribosyl Cyclase 1, Drug Resistance, Multiple, Neoplasm Proteins, Drug Resistance, Neoplasm, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Antigens, Surface, Biomarkers, Tumor, Neoplastic Stem Cells, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, ATP-Binding Cassette Transporters, ATP Binding Cassette Transporter, Subfamily B, Member 1, Multidrug Resistance-Associated Proteins, K562 Cells
ATP Binding Cassette Transporter, Subfamily B, Binding Sites, Membrane Glycoproteins, Gene Expression Regulation, Leukemic, Antigens, CD34, ADP-ribosyl Cyclase 1, Drug Resistance, Multiple, Neoplasm Proteins, Drug Resistance, Neoplasm, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Antigens, Surface, Biomarkers, Tumor, Neoplastic Stem Cells, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, ATP-Binding Cassette Transporters, ATP Binding Cassette Transporter, Subfamily B, Member 1, Multidrug Resistance-Associated Proteins, K562 Cells
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