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Virology
Article . 1992 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Virology
Article . 1992
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Comparison of the S RNA segments and nucleoprotein sequences of crimean-congo hemorrhagic fever, hazara, and dugbe viruses

Authors: A C, Marriott; P A, Nuttall;

Comparison of the S RNA segments and nucleoprotein sequences of crimean-congo hemorrhagic fever, hazara, and dugbe viruses

Abstract

The S RNA segments of the nairoviruses Crimean-Congo hemorrhagic fever (CCHF) virus (Chinese isolate) and Hazara (HAZ) virus were cloned and sequenced from PCR products. The RNAs comprise 1672 and 1677 nucleotides, respectively, and each encodes a protein in the viral complementary strand (54.0 and 54.2 kDa, respectively). The deduced protein sequences show homology to each other and to the nucleoprotein of Dugbe (DUG) nairovirus, although both the CCHF and HAZ viral proteins are larger. Alignment of the nucleoprotein sequences of CCHF, HAZ, and DUG viruses show that the CCHF and HAZ sequences are somewhat more closely related to each other (60.0% identity) than either is to the DUG sequence (55.4 and 53.0% identity, respectively); 39.5% of residues are identical across all three proteins. The carboxyl-terminus of DUG N protein shows a 40-residue deletion relative to the N proteins of the other two viruses.

Related Organizations
Keywords

Viral Structural Proteins, Base Sequence, Genes, Viral, Molecular Sequence Data, Viral Proteins, Nucleoproteins, Nairovirus, Hemorrhagic Fever Virus, Crimean-Congo, RNA, Viral, Amino Acid Sequence, Sequence Alignment

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Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
41
Top 10%
Top 10%
Average