Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
Copyright policy )Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. To determine the functional roles of Mmp13, we generated Mmp13 -null mice that showed profound defects in growth plate cartilage with markedly increased hypertrophic domains as well as delay in endochondral ossification and formation and vascularization of primary ossification centers. Absence of Mmp13 resulted in significant interstitial collagen accumulation due, in part, to the lack of appropriate collagenase-mediated cleavage that normally occurs in growth plates and primary ossification centers. Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development.
- Tokyo University of Agriculture and Technology Japan
- University of Oviedo Spain
- Harvard University United States
Mice, Knockout, Histocytochemistry, Ossification, Heterotopic, Extremities, Embryo, Mammalian, Mice, Cartilage, Phenotype, Matrix Metalloproteinase 13, Animals, Collagenases, Growth Plate, Exostoses, Multiple Hereditary
Mice, Knockout, Histocytochemistry, Ossification, Heterotopic, Extremities, Embryo, Mammalian, Mice, Cartilage, Phenotype, Matrix Metalloproteinase 13, Animals, Collagenases, Growth Plate, Exostoses, Multiple Hereditary
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).509 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!