CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking
Copyright policy )CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking
To investigate the association between polymorphisms in the human CYP2A6 gene, CYP2A6 enzyme activity and the influence of cigarette smoking in a Thai population.Coumarin (5 mg capsule) was administered to 194 healthy Thai subjects. Genetic variation of the CYP2A6 gene was identified using PCR methods. The excreted dose of 7-hydroxycoumarin (as a percentage of the urine concentration) 2 h after administration was calculated as an index of coumarin metabolism.The frequencies of CYP2A6 alleles *1A, *1B, *4C, *7, *8, *9 and *10 were 34.0, 35.3, 9.3, 6.4, 0.5, 12.1 and 2.4%, respectively. Of the 194 subjects tested, the number (percentages) of Thai participants classified as ultra-rapid, extensive, intermediate and poor metabolizers were 8 (4.1%), 159 (82.0%) 22 (11.3%) and five (2.6%), respectively.A relationship between the interindividual differences in coumarin metabolism and genetic polymorphisms of the CYP2A6 gene was observed.
- University of Queensland Australia
- Thammasat University Thailand
- University of Queensland Australia
- Khon Kaen University Thailand
- University of Queensland Australia
Adult, Male, Genotype, Cytochrome P450, Cytochrome P-450 CYP2A6, Young Adult, Asian People, Coumarins, 2736 Pharmacology (medical), Humans, Alleles, Genetic polymorphism, Polymorphism, Genetic, Smoking, Anticoagulants, Coumarin 7-hydroxylation, Middle Aged, Thailand, 3004 Pharmacology, Phenotype, Female, Aryl Hydrocarbon Hydroxylases, Genotyping–phenotyping, Oxidation-Reduction
Adult, Male, Genotype, Cytochrome P450, Cytochrome P-450 CYP2A6, Young Adult, Asian People, Coumarins, 2736 Pharmacology (medical), Humans, Alleles, Genetic polymorphism, Polymorphism, Genetic, Smoking, Anticoagulants, Coumarin 7-hydroxylation, Middle Aged, Thailand, 3004 Pharmacology, Phenotype, Female, Aryl Hydrocarbon Hydroxylases, Genotyping–phenotyping, Oxidation-Reduction
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