DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate
Copyright policy )DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate
The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experimental approaches. Topoisomerase I was stimulated by cAMP in a whole cell extract in a phosphorylation-dependent manner. These results suggest that topoisomerase I could be a target for nuclear events induced by peptide hormone action.
- University of Buenos Aires Argentina
- National Scientific and Technical Research Council Argentina
- Experimental Medicine and Biology Institute Argentina
Male, Intracellular Signaling Peptides and Proteins, Leydig Cells, Rats, Inbred Strains, In Vitro Techniques, Luteinizing Hormone, Rats, DNA Topoisomerases, Type I, Cyclic AMP, Animals, Testosterone, Carrier Proteins, Gonadotropins
Male, Intracellular Signaling Peptides and Proteins, Leydig Cells, Rats, Inbred Strains, In Vitro Techniques, Luteinizing Hormone, Rats, DNA Topoisomerases, Type I, Cyclic AMP, Animals, Testosterone, Carrier Proteins, Gonadotropins
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