Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution
Copyright policy )Dlk1 Promotes a Fast Motor Neuron Biophysical Signature Required for Peak Force Execution
Quick, Quick, Slow The slow muscles of postural stability and the fast muscles of running and jumping are driven by motor neurons that are differentiated by fast and slow biophysical properties. By retrograde labeling of mouse and chick muscle fibers, Müller et al. (p. 1264 ) characterized the developmental distinctions between fast and slow motor neurons. A transmembrane protein, when over- or underexpressed, was discovered to drive specification of the motor neurons and a downstream effector specified some, but not all, of the biophysical attributes.
- Max Planck Society Germany
- Nova Scotia Health Authority Canada
- University of Castile-La Mancha Spain
- University of Göttingen Germany
- Eni (Italy) Italy
Mice, Knockout, Motor Neurons, Receptors, Notch, Movement, Calcium-Binding Proteins, Muscle Fibers, Skeletal, Mice, Gene Expression Regulation, Potassium Channels, Voltage-Gated, Animals, Intercellular Signaling Peptides and Proteins, Muscle, Skeletal, Transcriptome, Signal Transduction
Mice, Knockout, Motor Neurons, Receptors, Notch, Movement, Calcium-Binding Proteins, Muscle Fibers, Skeletal, Mice, Gene Expression Regulation, Potassium Channels, Voltage-Gated, Animals, Intercellular Signaling Peptides and Proteins, Muscle, Skeletal, Transcriptome, Signal Transduction
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