Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease
Copyright policy )Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease
Mouse models indicate that mutant huntingtin promotes anabolic signaling to contribute to Huntington’s disease.
- Harvard University United States
- Scripps Research Institute United States
- University of Trento Italy
- Massachusetts General Hospital United States
Animals; Blotting, Western; Cell Line, Tumor; Cell Size; Corpus Striatum; Genetic Vectors; HEK293 Cells; Humans; Huntington Disease; Kaplan-Meier Estimate; Mice; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Nerve Tissue Proteins; Neuropeptides; RNA, Small Interfering; Rotarod Performance Test; Signal Transduction; Statistics, Nonparametric; TOR Serine-Threonine Kinases; Biochemistry; Cell Biology; Molecular Biology; Medicine (all), Huntingtin Protein, Blotting, Western, Genetic Vectors, Neuropeptides, Nerve Tissue Proteins, Kaplan-Meier Estimate, Mechanistic Target of Rapamycin Complex 1, Corpus Striatum, Mice, HEK293 Cells, Huntington Disease, Cell Line, Tumor, Multiprotein Complexes, Rotarod Performance Test, Animals, Humans, Ras Homolog Enriched in Brain Protein, RNA, Small Interfering, Cell Size, Monomeric GTP-Binding Proteins
Animals; Blotting, Western; Cell Line, Tumor; Cell Size; Corpus Striatum; Genetic Vectors; HEK293 Cells; Humans; Huntington Disease; Kaplan-Meier Estimate; Mice; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Nerve Tissue Proteins; Neuropeptides; RNA, Small Interfering; Rotarod Performance Test; Signal Transduction; Statistics, Nonparametric; TOR Serine-Threonine Kinases; Biochemistry; Cell Biology; Molecular Biology; Medicine (all), Huntingtin Protein, Blotting, Western, Genetic Vectors, Neuropeptides, Nerve Tissue Proteins, Kaplan-Meier Estimate, Mechanistic Target of Rapamycin Complex 1, Corpus Striatum, Mice, HEK293 Cells, Huntington Disease, Cell Line, Tumor, Multiprotein Complexes, Rotarod Performance Test, Animals, Humans, Ras Homolog Enriched in Brain Protein, RNA, Small Interfering, Cell Size, Monomeric GTP-Binding Proteins
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