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The finished DNA sequence of human chromosome 12

descriptionPublicationkeyboard_double_arrow_right Article 16 Mar 2006 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 440, pages 346-351 (issn: 0028-0836, eissn: 1476-4687,

Authors: Steven E, Scherer; Donna M, Muzny; Christian J, Buhay; Rui, Chen; Andrew, Cree; Yan, Ding; Shannon, Dugan-Rocha; +193 Authors

Steven E, Scherer; Donna M, Muzny; Christian J, Buhay; Rui, Chen; Andrew, Cree; Yan, Ding; Shannon, Dugan-Rocha; Rachel, Gill; Preethi, Gunaratne; R Alan, Harris; Alicia C, Hawes; Judith, Hernandez; Anne V, Hodgson; Jennifer, Hume; Andrew, Jackson; Ziad Mohid, Khan; Christie, Kovar-Smith; Lora R, Lewis; Ryan J, Lozado; Michael L, Metzker; Aleksandar, Milosavljevic; George R, Miner; Kate T, Montgomery; Margaret B, Morgan; Lynne V, Nazareth; Graham, Scott; Erica, Sodergren; Xing-Zhi, Song; David, Steffen; Ruth C, Lovering; David A, Wheeler; Kim C, Worley; Yi, Yuan; Zhengdong, Zhang; Charles Q, Adams; M Ali, Ansari-Lari; Mulu, Ayele; Mary J, Brown; Guan, Chen; Zhijian, Chen; Kerstin P, Clerc-Blankenburg; Clay, Davis; Oliver, Delgado; Huyen H, Dinh; Heather, Draper; Manuel L, Gonzalez-Garay; Paul, Havlak; Laronda R, Jackson; Leni S, Jacob; Susan H, Kelly; Li, Li; Zhangwan, Li; Jing, Liu; Wen, Liu; Jing, Lu; Manjula, Maheshwari; Bao-Viet, Nguyen; Geoffrey O, Okwuonu; Shiran, Pasternak; Lesette M, Perez; Farah J H, Plopper; Jireh, Santibanez; Hua, Shen; Paul E, Tabor; Daniel, Verduzco; Lenee, Waldron; Qiaoyan, Wang; Gabrielle A, Williams; Jingkun, Zhang; Jianling, Zhou; Carlana C, Allen; Anita G, Amin; Vivian, Anyalebechi; Michael, Bailey; Joseph A, Barbaria; Kesha E, Bimage; Nathaniel P, Bryant; Paula E, Burch; Carrie E, Burkett; Kevin L, Burrell; Eliana, Calderon; Veronica, Cardenas; Kelvin, Carter; Kristal, Casias; Iracema, Cavazos; Sandra R, Cavazos; Heather, Ceasar; Joseph, Chacko; Sheryl N, Chan; Dean, Chavez; Constantine, Christopoulos; Joseph, Chu; Raynard, Cockrell; Caroline D, Cox; Michelle, Dang; Stephanie R, Dathorne; Robert, David; Candi Mon'Et, Davis; Latarsha, Davy-Carroll; Denise R, Deshazo; Jeremy E, Donlin; Lisa, D'Souza; Kristy A, Eaves; Rain, Simons; Alexandra J, Emery-Cohen; Michael, Escotto; Nicole, Flagg; Lisa D, Forbes; Abdul M, Gabisi; Melissa, Garza; Cerissa, Hamilton; Nicholas, Henderson; Omar, Hernandez; Sandra, Hines; Marilyn E, Hogues; Mei, Huang; DeVincent G, Idlebird; Rudy, Johnson; Angela, Jolivet; Sally, Jones; Ryan, Kagan; Laquisha M, King; Belita, Leal; Heather, Lebow; Sandra, Lee; Jaclyn M, LeVan; Lakeshia C, Lewis; Pamela, London; Lorna M, Lorensuhewa; Hermela, Loulseged; Demetria A, Lovett; Alice, Lucier; Raymond L, Lucier; Jie, Ma; Renita C, Madu; Patricia, Mapua; Ashley D, Martindale; Evangelina, Martinez; Elizabeth, Massey; Samantha, Mawhiney; Michael G, Meador; Sylvia, Mendez; Christian, Mercado; Iracema C, Mercado; Christina E, Merritt; Zachary L, Miner; Emmanuel, Minja; Teresa, Mitchell; Farida, Mohabbat; Khatera, Mohabbat; Baize, Montgomery; Niki, Moore; Sidney, Morris; Mala, Munidasa; Robin N, Ngo; Ngoc B, Nguyen; Elizabeth, Nickerson; Ogechi O, Nwaokelemeh; Stanley, Nwokenkwo; Melissa, Obregon; Maryann, Oguh; Njideka, Oragunye; Rodolfo J, Oviedo; Bridgette J, Parish; David N, Parker; Julia, Parrish; Kenya L, Parks; Heidie A, Paul; Brett A, Payton; Agapito, Perez; William, Perrin; Adam, Pickens; Eltrick L, Primus; Ling-Ling, Pu; Maria, Puazo; Miyo M, Quiles; Juana B, Quiroz; Dina, Rabata; Kacy, Reeves; San Juana, Ruiz; Hongmei, Shao; Ida, Sisson; Titilola, Sonaike; Richard P, Sorelle; Angelica E, Sutton; Amanda F, Svatek; Leah Anne, Svetz; Kavitha S, Tamerisa; Tineace R, Taylor; Brian, Teague; Nicole, Thomas; Rachel D, Thorn; Zulma Y, Trejos; Brenda K, Trevino; Ogechi N, Ukegbu; Jeremy B, Urban; Lydia I, Vasquez; Virginia A, Vera; Donna M, Villasana; Ling, Wang;

doi: 10.1038/nature04569

pmid: 16541075

The finished DNA sequence of human chromosome 12

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Abstract

Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing approximately 4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.

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Keywords

Expressed Sequence Tags, Base Composition, Chromosomes, Human, Pair 12, Pan troglodytes, Molecular Sequence Data, Sequence Analysis, DNA, Synteny, Linkage Disequilibrium, Evolution, Molecular, Mutagenesis, Insertional, Genes, Animals, Humans, CpG Islands, Microsatellite Repeats, Sequence Deletion, Short Interspersed Nucleotide Elements

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