Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors
Copyright policy )Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors
In the mouse model of pancreas endocrine tumor, loss of Vegf (VKO) results in dramatically decreased tumor progression; however, the residual microscopic lesions show increased invasion into surrounding exocrine tissue. Double KO mice of Vegf and hypoxia inducible factor-1α (Hif-1α) showed increased life span and suppressed tumor growth due to increased apoptosis. The increased invasiveness of tumors in VKO mice was diminished in DKO mice to the levels of wild-type mice. Compared to VKO mice, DKO mice also exhibited smaller changes in the expression levels of adhesion molecules, including E-cadherin, N-cadherin, and NCAM. These changes of adhesion molecules were not observed in the primary culture of the tumor cells under hypoxic conditions. Thus, the invasive phenotype observed under angiogenesis inhibition requires Hif-1α, but is not directly caused by acute hypoxia.
Mice, Knockout, Vascular Endothelial Growth Factor A, Cell Survival, GTPase-Activating Proteins, Adenoma, Islet Cell, Hypoxia-Inducible Factor 1, alpha Subunit, Article, Disease Models, Animal, Mice, Phenotype, Animals, Neoplasm Invasiveness, Hypoxia, Cell Adhesion Molecules, Gene Deletion
Mice, Knockout, Vascular Endothelial Growth Factor A, Cell Survival, GTPase-Activating Proteins, Adenoma, Islet Cell, Hypoxia-Inducible Factor 1, alpha Subunit, Article, Disease Models, Animal, Mice, Phenotype, Animals, Neoplasm Invasiveness, Hypoxia, Cell Adhesion Molecules, Gene Deletion
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