Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population
Copyright policy )Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population
Recently a relationship between serotonin transporter transcriptional control region (5-HTTLPR) polymorphism and anxiety related personality traits in Caucasians was reported. We performed PCR of DNAs from the blood for determining the 5-HTTLPR genotypes of 191 Japanese subjects, which were medical staff and students, and obtained Revised NEO Personality Inventory (NEO-PI-R) and the Temperament and Character Inventory (TCI) in 144 subjects. The association was analyzed by one-way ANOVA. The present study demonstrated that allelic frequency of 5-HTTLPR (s allele frequency was 0.785) in our subjects was considerably different from that in Caucasians. No significant differences were found in the anxiety-related personality traits among genotypes, while cooperativeness in TCI showed a significant difference among genotypes. The property of 5-HTTLPR may not be reflected directory on the personality inventories.
- Chiba University Japan
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Personality Inventory, Membrane Transport Proteins, Nerve Tissue Proteins, DNA, Regulatory Sequences, Nucleic Acid, White People, Asian People, Gene Frequency, Japan, Humans, Female, Carrier Proteins, Alleles, Personality
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Personality Inventory, Membrane Transport Proteins, Nerve Tissue Proteins, DNA, Regulatory Sequences, Nucleic Acid, White People, Asian People, Gene Frequency, Japan, Humans, Female, Carrier Proteins, Alleles, Personality
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