Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5‐HTTLPR‐S) and the CYP2C9*3 allele
Copyright policy )Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5‐HTTLPR‐S) and the CYP2C9*3 allele
AbstractIn the present study, we aimed to analyze the potential relevance of the polymorphism in the promoter region of the serotonin transporter (SERT or 5‐HTT) gene (5‐HTTLPR) and the risk of suffering major depression (MDD) in a population of patients previously genotyped for CYP2C9. Seventy white European psychiatric outpatients suffering from MDD and a group of 142 healthy volunteers (HVs) were studied. The frequency of subjects carrying the 5‐HTTLPR‐S allele was higher (P < 0.05) among MDD than in HV. The odds ratio associated with 5‐HTTLPR‐S allele was 2.03 for the MDD patients in comparison with the HV group. Previously, we found in this population that the CYP2C9*3 allele frequency was higher among this population of MDD patients than in HV. The frequency of subjects with the combination 5‐HTTLPR‐S and CYP2C9*3 alleles was higher (P < 0.01, odds ratio 3.47) in MDD than in HV. The present findings provide preliminary evidence about the greater risk of suffering MDD for individuals carrying both 5‐HTTLPR‐S and CYP2C9*3 alleles.
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Depressive Disorder, Major, Polymorphism, Genetic, Genotype, Middle Aged, Gene Frequency, Risk Factors, Humans, Female, Genetic Predisposition to Disease, Aryl Hydrocarbon Hydroxylases, Promoter Regions, Genetic, Alleles, Cytochrome P-450 CYP2C9
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Depressive Disorder, Major, Polymorphism, Genetic, Genotype, Middle Aged, Gene Frequency, Risk Factors, Humans, Female, Genetic Predisposition to Disease, Aryl Hydrocarbon Hydroxylases, Promoter Regions, Genetic, Alleles, Cytochrome P-450 CYP2C9
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