Characterization of the submicroscopic deletion in the small‐cell lung carcinoma (SCLC) cell line U2020
Copyright policy )Characterization of the submicroscopic deletion in the small‐cell lung carcinoma (SCLC) cell line U2020
AbstractThe small‐cell lung carcinoma cell line U2020 contains a submicroscopic, homozygous deletion that removes a chromosomal segment within 3p13‐p14, including the locus D3S3. We have sublocalized 49 additional probes to the 3p13‐p14.2 region and have identified 7 new DNA markers that arise from within the U2020 deletion. The estimated size of the deletion, based on marker density, is approximately 4–5 megabases (Mb). Including D3S3, 7 of the 8 markers have been linked by pulsed‐field gel (PFG) electrophoresis over an area of approximately 2 Mb. Including the one unlinked marker, PFG analysis accounts for about 3 Mb of the region. The U2020 deletion appears confined to the 3p13‐p14.2 region and does not include the candidate tumor suppressor gene, protein‐tyrosine phosphatase gamma (PTPG).
- Uppsala University Sweden
- University of Colorado Boulder United States
- University of Colorado Cancer Center United States
- Uppsala University Hospital Sweden
- Akademiska Barnsjukhuset Sweden
Genetic Markers, Lung Neoplasms, Genetic Linkage, Tumor Cells, Cultured, Humans, Chromosomes, Human, Pair 3, Carcinoma, Small Cell, Chromosome Deletion, Protein Tyrosine Phosphatases, DNA Probes, Electrophoresis, Gel, Pulsed-Field
Genetic Markers, Lung Neoplasms, Genetic Linkage, Tumor Cells, Cultured, Humans, Chromosomes, Human, Pair 3, Carcinoma, Small Cell, Chromosome Deletion, Protein Tyrosine Phosphatases, DNA Probes, Electrophoresis, Gel, Pulsed-Field
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