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Developmental Biology
Article
License: Elsevier Non-Commercial
Data sources: UnpayWall
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Developmental Biology
Article . 2016
License: Elsevier Non-Commercial
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Developmental Biology
Article . 2016 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
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A newly identified type of attachment cell is critical for normal patterning of chordotonal neurons

Authors: Adi Salzberg; Atalya Nachman; Naomi Halachmi;

A newly identified type of attachment cell is critical for normal patterning of chordotonal neurons

Abstract

This work describes unknown aspects of chordotonal organ (ChO) morphogenesis revealed in post-embryonic stages through the use of new fluorescently labeled markers. We show that towards the end of embryogenesis a hitherto unnoticed phase of cell migration commences in which the cap cells of the ventral ChOs elongate and migrate towards their prospective attachment sites. This migration and consequent cell attachment generates a continuous zigzag line of proprioceptors, stretching from the ventral midline to a dorsolateral position in each abdominal segment. Our observation that the cap cell of the ventral-most ChO attaches to a large tendon cell near the midline provides the first evidence for a direct physical connection between the contractile and proprioceptive systems in Drosophila. Our analysis has also provided an answer to a longstanding enigma that is what anchors the neurons of the ligamentless ventral ChOs on their axonal side. We identified a new type of ChO attachment cell, which binds to the scolopale cells of these organs, thus behaving like a ligament cell, but on the other hand exhibits all the typical features of a ChO attachment cell and is critical for the correct anchoring of these organs.

Keywords

Cell Differentiation, Cell Biology, Proprioception, Animals, Genetically Modified, Drosophila melanogaster, Cell Movement, Larva, Animals, Molecular Biology, Mechanoreceptors, Developmental Biology

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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Average
Average
Top 10%
hybrid