The Drosophila Ret gene is transcribed in multiple alternatively spliced forms
Copyright policy )The Drosophila Ret gene is transcribed in multiple alternatively spliced forms
We have cloned and sequenced the 5' and 3' ends of the Drosophila homolog of the vertebrate c-ret gene, Ret, and have derived from it the predicted protein sequence of Ret. The extracellular domain of Ret is very widely diverged from that of its vertebrate counterparts but the cadherin motif present in vertebrate c-ret proteins can also be discerned in Ret. As with the vertebrate gene, multiple splice variants were detected at the 5'-end of Ret, one of which inserts an exon with a protein-terminating frameshift into the cDNA. In contrast to human c-ret, which may vary its signalling specificity by using splicing-derived, alternative C-terminal sequences, Ret cDNAs showed no variation at their 3'-ends.
- University of Cambridge United Kingdom
- Cambridge University Hospitals NHS Foundation Trust United Kingdom
- Addenbrooke's Hospital United Kingdom
DNA, Complementary, Base Sequence, Models, Genetic, Molecular Sequence Data, Proto-Oncogene Proteins c-ret, Exons, Blotting, Northern, Cadherins, Polymerase Chain Reaction, Protein Structure, Tertiary, Alternative Splicing, Proto-Oncogene Proteins, Animals, Drosophila Proteins, Humans, Insect Proteins, RNA, Drosophila, Amino Acid Sequence, Cloning, Molecular
DNA, Complementary, Base Sequence, Models, Genetic, Molecular Sequence Data, Proto-Oncogene Proteins c-ret, Exons, Blotting, Northern, Cadherins, Polymerase Chain Reaction, Protein Structure, Tertiary, Alternative Splicing, Proto-Oncogene Proteins, Animals, Drosophila Proteins, Humans, Insect Proteins, RNA, Drosophila, Amino Acid Sequence, Cloning, Molecular
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