Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample
Copyright policy )Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample
A role of dopaminergic dysfunction has been postulated in the aetiology of schizophrenia. We hypothesized that variations in the dopamine transporter gene (SLC6A3) may be associated with schizophrenia. We conducted case-control and family based analysis on the polymorphic SLC6A3 variable number tandem repeat (VNTR) in a sample of 220 schizophrenic patients, 226 gender and ethnic matched controls, and 49 additional case-parent trios. No differences were found in allelic or genotypic distributions between cases and controls and no significant transmission distortions from heterozygous parents to schizophrenic offspring were detected. Thus, our results do not support an association of the SLC6A3 VNTR with schizophrenia in our sample.
- Universidade de São Paulo Brazil
- UNIVERSIDADE DE SAO PAULO Brazil
- University of Pittsburgh United States
- University of Pittsburgh School of Medicine United States
- University of Pittsburgh School of Medicine United States
SLC6A3, trios, Male, Dopamine Plasma Membrane Transport Proteins, Polymorphism, Genetic, genetic association, Genotype, esquizofrenia, Minisatellite Repeats, polimorfismo genético, schizophrenia, DAT1, Case-Control Studies, Schizophrenia, genetic polymorphism, Humans, Female, Genetic Predisposition to Disease, associação genética, Alleles, Brazil
SLC6A3, trios, Male, Dopamine Plasma Membrane Transport Proteins, Polymorphism, Genetic, genetic association, Genotype, esquizofrenia, Minisatellite Repeats, polimorfismo genético, schizophrenia, DAT1, Case-Control Studies, Schizophrenia, genetic polymorphism, Humans, Female, Genetic Predisposition to Disease, associação genética, Alleles, Brazil
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