High Throughput Screening of Biologically Functional Small Molecules for Modulating the Expression of FGFR1OP2/wit3.0 in Fibroblasts
Copyright policy )High Throughput Screening of Biologically Functional Small Molecules for Modulating the Expression of FGFR1OP2/wit3.0 in Fibroblasts
Oral wounds heal rapidly without scarring through yet unknown molecular mechanisms. A small cytoskeleton molecule identified in oral wound fibroblasts, FGFR1OP2/wit3.0, has been shown to accelerate wound closure in vitro and in vivo. The objective of this study was to elucidate the transcriptional mechanism of FGFR1OP2/ wit3.0 in fibroblasts using a high throughput drug-screening platform. This pilot study identified chemical compounds that could effectively modulate the FGFR1OP2/wit3.0 expression for future studies on effective wound management.
- University of California, Los Angeles United States
Cytoplasm, Microscopy, Confocal, Cell Culture Techniques, Mice, Inbred Strains, Pilot Projects, Fibroblasts, Actins, Cell Line, High-Throughput Screening Assays, Mice, Inbred C57BL, Cytoskeletal Proteins, Mice, Gene Knockdown Techniques, Mutation, Animals, Gene Silencing, RNA, Small Interfering, Cell Shape, Cells, Cultured, Embryonic Stem Cells
Cytoplasm, Microscopy, Confocal, Cell Culture Techniques, Mice, Inbred Strains, Pilot Projects, Fibroblasts, Actins, Cell Line, High-Throughput Screening Assays, Mice, Inbred C57BL, Cytoskeletal Proteins, Mice, Gene Knockdown Techniques, Mutation, Animals, Gene Silencing, RNA, Small Interfering, Cell Shape, Cells, Cultured, Embryonic Stem Cells
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