Distribution of α2-adrenoceptor mRNAs in the rat lumbar spinal cord in normal and axotomized rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1999 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:NeuroReport, volume 10, pages 2,835-2,839 (issn: 0959-4965,

Authors: T J, Shi; U, Winzer-Serhan; F, Leslie; T, Hökfelt;

doi: 10.1097/00001756-199909090-00025

pmid: 10511449

Distribution of α2-adrenoceptor mRNAs in the rat lumbar spinal cord in normal and axotomized rats

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Abstract

Using riboprobe in situ hybridization we have studied the distribution of alpha2A-, alpha2B- and alpha2c-adrenoceptor (AR) mRNAs in the lumbar spinal cord in normal rats and after peripheral axotomy. A strong alpha2A- and alpha2C AR mRNA labelling was found in motoneurons and other cells in the ventral horns. In the dorsal horns strong alpha2A-AR mRNA labelling was found in all layers and in the lateral spinal nucleus, whereas alpha2C-AR mRNA was found in lower numbers of cells in various layers. The alpha2B-AR mRNA signal was only detected in some small cells superficially in the dorsal horn. With regard to axotomy only a marginal effect was observed for alpha2C-AR mRNA in the ventral horn. The results suggest that alpha2-ARs are involved both in sensory and motor processing.

Related Organizations

Karolinska Institute
Sweden
Virginia Commonwealth University Medical Center
United States
University of California, Irvine
United States

Keywords

Male, Neurons, Lumbosacral Region, Axotomy, Receptors, Adrenergic, alpha, Rats, Rats, Sprague-Dawley, Spinal Cord, Reference Values, Animals, Protein Isoforms, Tissue Distribution, RNA, Messenger, In Situ Hybridization

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