Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity
Copyright policy )Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity
Staphylococcus aureus and many other bacterial pathogens rely on metal-binding small molecules to obtain the essential metal zinc during infection. In this study, we reveal that export of these small molecules is critical for overcoming host-imposed metal starvation during infection and prevents toxicity due to accumulation of the metal-binding molecule within the cell. Surprisingly, we found that intracellular toxicity of the molecule is not due to chelation of cellular metals.
- University of Melbourne Australia
- University of Illinois at Urbana–Champaign United States
- University of Adelaide Australia
- UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- University of Illinois at Urbana Champaign United States
570, Staphylococcus aureus, 572, Imidazoles, nutritional immunity, Staphylococcal Infections, calprotectin, 540, staphylopine, Mice, Inbred C57BL, Mice, Zinc, Bacterial Proteins, zincophore, pseudopaline, Animals, Humans, Female
570, Staphylococcus aureus, 572, Imidazoles, nutritional immunity, Staphylococcal Infections, calprotectin, 540, staphylopine, Mice, Inbred C57BL, Mice, Zinc, Bacterial Proteins, zincophore, pseudopaline, Animals, Humans, Female
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