Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
Copyright policy )Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
A scavenger that protects the heart Coronary heart disease is a tale of two forms of plasma cholesterol. In contrast to the well-established effects of “bad” cholesterol (LDL-C), the role of “good” cholesterol (HDL-C) is mysterious. Elevated HDL-C correlates with a lower risk of heart disease, yet drugs that raise HDL-C levels do not reduce risk. Zanoni et al. found that some people with exceptionally high levels of HDL-C carry a rare sequence variant in the gene encoding the major HDL-C receptor, scavenger receptor BI. This variant destroys the receptor's ability to take up HDL-C. Interestingly, people with this variant have a higher risk of heart disease despite having high levels of HDL-C. Science , this issue p. 1166
Netherlands Twin Register (NTR), Male, Risk, Heterozygote, HDL, Scavenger Receptors, Proline, DNA Mutational Analysis, Coronary Disease, Research Support, N.I.H., Aged; Amino Acid Substitution; Animals; Cholesterol, HDL/blood; Coronary Disease/blood; Coronary Disease/genetics; DNA Mutational Analysis; Female; Genetic Variation; Heterozygote; Homozygote; Humans; Leucine/genetics; Male; Mice; Middle Aged; Proline/genetics; Protein Processing, Post-Translational; Risk; Scavenger Receptors, Class B/genetics; Scavenger Receptors, Class B/metabolism, scavenger receptor, Mice, Leucine, Journal Article, Animals, Humans, Non-U.S. Gov't, Protein Processing, increased atherosclerosis, Aged, levels of plasma, Cholesterol, HDL, Homozygote, Post-Translational, Extramural, Genetic Variation, Middle Aged, Scavenger Receptors, Class B, [SDV] Life Sciences [q-bio], Cholesterol, Amino Acid Substitution, Female, Class B, Protein Processing, Post-Translational
Netherlands Twin Register (NTR), Male, Risk, Heterozygote, HDL, Scavenger Receptors, Proline, DNA Mutational Analysis, Coronary Disease, Research Support, N.I.H., Aged; Amino Acid Substitution; Animals; Cholesterol, HDL/blood; Coronary Disease/blood; Coronary Disease/genetics; DNA Mutational Analysis; Female; Genetic Variation; Heterozygote; Homozygote; Humans; Leucine/genetics; Male; Mice; Middle Aged; Proline/genetics; Protein Processing, Post-Translational; Risk; Scavenger Receptors, Class B/genetics; Scavenger Receptors, Class B/metabolism, scavenger receptor, Mice, Leucine, Journal Article, Animals, Humans, Non-U.S. Gov't, Protein Processing, increased atherosclerosis, Aged, levels of plasma, Cholesterol, HDL, Homozygote, Post-Translational, Extramural, Genetic Variation, Middle Aged, Scavenger Receptors, Class B, [SDV] Life Sciences [q-bio], Cholesterol, Amino Acid Substitution, Female, Class B, Protein Processing, Post-Translational
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