Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer
Copyright policy )Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer
Significance Redox regulation of breast cancer underlies malignant progression. Loss of the antioxidant glutathione peroxidase 2 in breast cancer cells increases reactive oxygen species, thereby activating hypoxia inducible factor-α (HIF1α) signaling. This in turn causes vascular malfunction, resulting in hypoxia and metabolic heterogeneity. HIF1α suppresses oxidative phosphorylation and stimulates glycolysis (the Warburg effect) in most of the tumor, except for one cancer subpopulation, which was capable of using both metabolic modalities. Hence, adopting a hybrid metabolic state may allow tumor cells to survive under aerobic or hypoxic conditions, a vulnerability that may be exploited for therapeutic targeting by either metabolic or redox-based strategies.
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland, Australian Institute for Bioengineering and Nanotechnology Australia
- University of Queensland Australia
Vascular Endothelial Growth Factor A, Cell Plasticity, neoplasms, mammal, Oxidative Phosphorylation, Mice, gender, animal, tissues types and functions, modification, Neovascularization, Pathologic, phosphorylation, cancer types, rodent, bioinformatics, cell line, Biological Sciences, female, diseases & disorders, Female, cell types, cell types and functions, Glycolysis, Oxidation-Reduction, signal transduction, Signal Transduction, Mice, Nude, Breast Neoplasms, breast cancer, Cell Line, Tumor, organs types and functions, cancer, Animals, Humans, genetics & nucleic acid processing, tissues, protein structure, protein expression, mouse, genomics and proteomics, function, Glutathione Peroxidase, Hypoxia-Inducible Factor 1, alpha Subunit, Xenograft Model Antitumor Assays, organelles, Metabolism, organs, Reactive Oxygen Species, metabolism, ddc: ddc:
Vascular Endothelial Growth Factor A, Cell Plasticity, neoplasms, mammal, Oxidative Phosphorylation, Mice, gender, animal, tissues types and functions, modification, Neovascularization, Pathologic, phosphorylation, cancer types, rodent, bioinformatics, cell line, Biological Sciences, female, diseases & disorders, Female, cell types, cell types and functions, Glycolysis, Oxidation-Reduction, signal transduction, Signal Transduction, Mice, Nude, Breast Neoplasms, breast cancer, Cell Line, Tumor, organs types and functions, cancer, Animals, Humans, genetics & nucleic acid processing, tissues, protein structure, protein expression, mouse, genomics and proteomics, function, Glutathione Peroxidase, Hypoxia-Inducible Factor 1, alpha Subunit, Xenograft Model Antitumor Assays, organelles, Metabolism, organs, Reactive Oxygen Species, metabolism, ddc: ddc:
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