Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
Copyright policy )Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
The biogenesis of exosomes, small secreted vesicles involved in signalling processes, remains incompletely understood. Here, we report evidence that the syndecan heparan sulphate proteoglycans and their cytoplasmic adaptor syntenin control the formation of exosomes. Syntenin interacts directly with ALIX through LYPX(n)L motifs, similarly to retroviral proteins, and supports the intraluminal budding of endosomal membranes. Syntenin exosomes depend on the availability of heparan sulphate, syndecans, ALIX and ESCRTs, and impact on the trafficking and confinement of FGF signals. This study identifies a key role for syndecan-syntenin-ALIX in membrane transport and signalling processes.
- Katholieke Universiteit Leuven Belgium
- VIB Belgium
- MRC Laboratory of Molecular Biology United Kingdom
- Medical Research Council United Kingdom
Binding Sites, Syndecans, Time Factors, Endosomal Sorting Complexes Required for Transport, Syntenins, Recombinant Fusion Proteins, Calcium-Binding Proteins, Cell Cycle Proteins, Exosomes, Receptors, Fibroblast Growth Factor, Fibroblast Growth Factors, Mice, Protein Transport, Cell Line, Tumor, Animals, Humans, Protein Interaction Domains and Motifs, RNA Interference, Heparitin Sulfate, Signal Transduction
Binding Sites, Syndecans, Time Factors, Endosomal Sorting Complexes Required for Transport, Syntenins, Recombinant Fusion Proteins, Calcium-Binding Proteins, Cell Cycle Proteins, Exosomes, Receptors, Fibroblast Growth Factor, Fibroblast Growth Factors, Mice, Protein Transport, Cell Line, Tumor, Animals, Humans, Protein Interaction Domains and Motifs, RNA Interference, Heparitin Sulfate, Signal Transduction
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